Abstract 2393 Using Translation Enhancing Elements to Improve mRNA-based Vaccinations

With mRNA-based vaccinations, the genomic material coding for a protein is directly delivered to cells using lipid nanoparticles. The mRNA is then translated by host cell ribosomes to produce the desired protein antigen. An individual's immune system will then mount an immune response to that antigen. To generate a protective immune response, the dosage of the mRNA-based vaccine must be at an appropriate level, however both the mRNA and lipid nanoparticle components of the vaccine trigger dose-dependent, transient systemic reactions such as fevers and chills.