Abstract 2308 Role of Novel Long Non-Coding RNAs in Neuroinflammation and Neurodegenerative diseases

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by dementia, memory loss, and cognitive decline, largely due to amyloid-beta (Aβ) plaque accumulation and tau hyperphosphorylation. Affecting nearly 7 million Americans and 50 million people globally, AD remains a critical health challenge. Emerging research highlights the central role of neuroinflammation in AD, primarily mediated by microglia, the brain's resident immune cells. A key factor in maintaining synaptic plasticity and cognitive health, brain-derived neurotrophic factor (BDNF) has been found to decrease in neurodegenerative diseases like AD, impacting neuron survival and function.