Abstract 1460 Selenoprotein O mediated protein AMPylation regulates mitochondrial metabolism
Selenoprotein O is one of only 25 selenoproteins that incorporate the 21st genetically encoded amino acid, selenocysteine. Despite the wide range of physiological importance, the biochemical activity of several selenoproteins remain a mystery. Selenoprotein O (SelO) is an evolutionarily conserved enzyme that catalyzes AMPylation, the covalent addition of AMP from ATP to protein substrates. SelO localizes to the mitochondria to AMPylate multiple key enzymes in cellular energy metabolism and redox biology.
Authors
- Kelly A. Servage (ORCID: https://orcid.org/0000-0001-7183-2865)
- Anju Sreelatha (ORCID: https://orcid.org/0000-0001-9485-0214)
- Krzysztof Pawłowski (ORCID: https://orcid.org/0000-0002-5367-0935)
- Alex Pon (ORCID: https://orcid.org/0009-0003-3230-8165)
- Yan Han (ORCID: https://orcid.org/0000-0002-4952-5153)
- Antonio Castro (ORCID: https://orcid.org/0000-0001-6664-8158)
Institutions
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.109889
- Primary Topic
- Selenium in Biological Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health