Abstract 1341 Proteomic analysis of Kdo2-lipid A and Lipid IVa-induced Toll-like receptor 4 and non-canonical inflammasome pathways: A gateway to understanding sepsis

Pathogen-associated molecular patterns (PAMPs) are conserved microbial structures recognized by the immune system to trigger host defense responses. Lipopolysaccharide (LPS), a prominent class of PAMPs found on gram-negative bacterial cell walls, is known for its potent immunostimulatory effects, largely mediated by its fatty acyl chains. Acyloxyacyl hydroxylase (AOAH) is a host lipase that attenuates immunogenicity by removing the secondary acyl chain from the lipid A of LPS. This process is crucial for preventing prolonged immunosuppression and maintaining homeostasis, which is important for managing sepsis.