Abstract 1921 Incorporation of methionine sulfoxides into nascent proteins during translation

Oxidation is a common amino acid modification found within proteins. Methionine (Met) is one amino acid which is highly susceptible to oxidation at the sulfur atom of its side chain. Once oxidized by reactive oxygen species (ROS), methionine is converted to methionine sulfoxide (MetO). This oxidation is enzymatically reversible by a set of highly conserved enzymes called methionine sulfoxide reductases (Msrs) that stereoselectively reduce MetO back to Met. However, if left unchecked, methionine oxidation can cause protein misfolding and has been linked to pathological aging and several neurodegenerative disorders such as Alzheimer's and Parkinson's diseases.