Abstract 1697 The Effect of Atg10 Activity on Autophagosome Size and Number

Macroautophagy, hereafter called autophagy, is a conserved cellular degradation pathway for trafficking materials from the cytoplasm to the vacuole/lysosome. This material is transported inside a double membrane vesicle, called an autophagosome, which is assembled in the cytoplasm, enveloping the cargo as it is formed. The outer membrane of the autophagosome fuses with the degradative compartment, so the inner membrane and cargo can be recycled. The induction of autophagy by nitrogen starvation in baker's yeast, Saccharomyces cerevisiae, involves the regulation of many autophagy related (Atg) proteins, such as Atg10.