Abstract 2391 Role of ATP-Citrate Lyase Subunits in Yarrowia lipolytica
ATP citrate lyase (ACL) is indispensable for lipid biosynthesis. It catalyzes the ATP-dependent conversion of citrate to acetyl-CoA, a key intermediate in both fatty acid and triacylglycerol (TAG) biosynthesis pathways. The Yarrowia lipolytica ACL is a heterodimeric enzyme consisting of catalytic Acl1 and regulatory Acl2 subunits. Previous research has shown that mutants lacking ACL1 or ACL2 present reduced lipid accumulation and altered lipid profiles. Furthermore, the ablation of ACL1 or ACL2 leads to a global transcriptional reprogramming, impacting the expression of thousands of genes.
Authors
- Stylianos Fakas (ORCID: https://orcid.org/0000-0001-8692-1326)
- Kenneth W. Jackson (ORCID: https://orcid.org/0000-0001-6700-1436)
- Ayodeji Odunsi (ORCID: https://orcid.org/0000-0003-4457-7648)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.109431
- Citations
- 1
- Primary Topic
- Microbial Metabolic Engineering and Bioproduction
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Science Foundation