Abstract 2653 Defining the allosteric activation network in human OAS1

Pattern recognition receptors (PRRs) of the innate immune system are an important class of proteins involved in the detection and elimination of infection by recognizing and binding to specific molecular structures associated with these pathogens. Dysregulation of these host responses can lead to heightened susceptibility to infection or autoimmune diseases. PRRs such as 2'-5' oligoadenylate synthetases (OAS) play a pivotal role in antiviral defense by sensing cytosolic double-stranded RNA (dsRNA), a hallmark of viral infection.