Abstract 2146 Fortilin binds CTNNA3 and protects it against phosphorylation, ubiquitination, and proteasomal degradation to guard cells against apoptosis

Fortilin is a ubiquitously expressed and highly conserved 172-amino acid polypeptide found in the cytosol, nucleus, mitochondria, extracellular space, and circulating blood. As a multifunctional protein, it plays diverse roles in cellular processes such as protecting cells from apoptosis, promoting growth, and regulating the cell cycle. These roles are mediated through its interactions with various proteins, where fortilin acts as a stabilizer or regulator, contributing to its involvement in several human diseases.