Abstract 2376 Nucleocytoplasmic shuttling of thyroid hormone receptor TRα1 acetylation and non-acetylation mimics

Human thyroid hormone receptor TRα1 modulates target gene expression in response to thyroid hormone (T3), but also undergoes nucleocytoplasmic shuttling and post-translational modification by acetylation. The current model for TR shuttling predicts that acetylation occurs in the nucleus, but it remains unclear whether TRα1's nuclear transport is influenced by its acetylation status. Here, we aimed to determine whether acetylation of TRα1 at the K130, K134, and K136 residues which reside in one of its nuclear localization signals, NLS-1, affects its ability to shuttle between the nucleus and cytoplasm.