Abstract 1555 Proinflammatory cytokines are differently regulated by STAT3 in trained innate immunity

Macrophages are important cells of innate immunity. They play an important role in the early stage of infection by phagocytizing microorganisms and secreting cytokines to recruit other immune cells to the inflammatory site. Macrophages were recently shown to be the main cell of the trained innate immunity, a concept in which a primary challenge can alter macrophage secondary response to a similar or different stimulus. Macrophages have many pattern recognition receptors known as Toll-like Receptors (TLRs) on their surface, allowing them to recognize a number of pathogen-associated molecular patterns (PAMPs).