Abstract 1545 Glycoprotein Analysis of Aged Mice Brain Proteome

Neurodegenerative diseases such as Alzheimer's disease are a major health concern, with approximately 1 in 9 people above the age of 65 suffering from Alzheimer's disease. Since aging is the primary risk factor for neurodegenerative diseases, understanding the biology of aging is critical for developing new therapies. To contribute to this goal, we recently performed a quantitative mass spectrometry to analyze the changes in protein abundances between adult and old mice brains. Our findings revealed that four proteins (Alg2, Mpi, Napa, and Rpn1), all involved in protein glycosylation, were significantly affected by aging.