Abstract 2552 Characterization of two novel peptides capable of inducing targeted degradation by a proteasome-independent mechanism

Targeted degradation by recruitment of biomolecules has therapeutic applications, but in order to be effective, targeted degradation requires moieties capable of inducing a degradation pathway. The moiety used affects degradation efficiency or which substrates can be targeted (proteins, organelles, etc.). Therefore, the discovery of new factors capable of degradation may open new possibilities in targeted degradation therapies. Using a high-throughput screen, we identified two RING finger containing peptides, HLTF;zf-C3HC4 and RO52;zf-C3HC4, capable of inducing degradation when recruited to a protein.