Abstract 2440 The Biophysical Interaction Between (-)-epi-gallocatechin gallate and Alpha-Synuclein Fibrils

The cellular lipid landscape serves as a critical determinant of cellular health, particularly in neurons where precise regulation of membrane composition is essential for proper function.This presentation will explore how alterations in cellular lipid composition and distribution influence the formation and function of membrane contact sites -specialized regions where organelles come into proximity to exchange materials and information.We will discuss how alteration of these essential cellular interfaces can lead to compromised organelle function, altered calcium signaling, and ultimately contribute to neurodegeneration.By understanding the fundamental relationship between lipids, membrane contact sites, and organelle communication, we gain crucial insights into potential therapeutic strategies for neurodegenerative disorders.Our findings highlight the importance of maintaining proper lipid homeostasis for neuronal health and survival.