Abstract 3002 Nanoscale examination of the invasion machinery of apicomplexan parasites reveals conservation and reorganization of its structure
The phylum Apicomplexa includes several of the most prevalent and important human eukaryotic pathogens, such as Plasmodium spp., which causes malaria, and Toxoplasma gondii, which causes toxoplasmosis. These obligatory intracellular parasites enter a host cell by deploying a remarkable machine at their anterior end known as the apical complex (AC), which is highly conserved and entirely specific to the ∼6000 species in the Apicomplexa phylum. The AC is comprised of subcellular organelles and distinct elements of the cytoskeleton.
Authors
- Michael Schmid (ORCID: https://orcid.org/0000-0003-3373-9357)
- Elizabeth S. Egan (ORCID: https://orcid.org/0000-0002-2112-7700)
- Stella Sun (ORCID: https://orcid.org/0000-0001-9004-8494)
- Wah Chiu (ORCID: https://orcid.org/0000-0002-8910-3078)
- Chi Yong Kim (ORCID: https://orcid.org/0000-0002-7508-3854)
- John C. Boothroyd (ORCID: https://orcid.org/0000-0001-9719-745X)
- Li-av Segev-Zarko (ORCID: https://orcid.org/0000-0003-4151-5513)
- Grigore Pintilie
Institutions
- The University of Texas Medical Branch at Galveston (US)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.109677
- Primary Topic
- Parasite Biology and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- Chemistry, Engineering and Medicine for Human Health, Stanford University