The possibilities of monitoring the effectiveness of anticoagulant therapy using a thrombodynamics test in patients with left atrial appendage thrombosis with non-valvular atrial fibrillation: clinical cases

Clinical observations of the possibility of using the thrombodynamics test (TD) in comparison with standard hemostasis tests in patients with non-valvular atrial fibrillation (AF) and detected thrombosis of the left atrial appendage against the background constant oral anticoagulants are presented. It has been shown that the transfer from one direct oral anticoagulant (DOACs) to another (with a different mechanism of action), as well as from DOACs to warfarin, can change the state of the blood plasma coagulation system towards both hyper- and hypocoagulation. Unlike standard hemostasis tests, TD can be used to assess the prothrombotic status of a patient with AF and personalized selection of effective anticoagulant therapy.