Abstract 2296 Unbiased proteomics and interactome analysis reveals MAGE-B2 regulates proliferation using varied binding partners

Melanoma antigen genes (MAGE) are a group of tumor specific genes that are normally expressed in male germline cells and aberrantly expressed in a wide range of cancers. Cancer patients expressing MAGE-B2, a member of the MAGE family show poor prognosis. Studies highlight MAGE-B2 to have high tumor inducing potential in mouse xenograft studies. The functional basis for MAGE-B2's tumorigenic, pro-proliferative effect is unclear and has been sparsely investigated. We seek to establish a mechanistic basis for MAGE-B2 function and understand the biochemical role of the MAGE family of proteins.