Abstract 2939 Developing RetroDecoys for Transcriptional Regulation

Transcription factors (TFs) bind short sequences of DNA to orchestrate the gene expression programs that define each cell's identity. A change in the abundance of even a single transcription factor can induce a pattern of gene expression that fundamentally alters the transcriptome and physiology of a cell. Double-stranded transcription factor decoy oligodeoxynucleotides (ODNs) are therapeutic drug candidates, which are able to specifically target and neutralize key transcription factors involved in the pathogenesis of a given disease.