Abstract 3058 Protein Tyrosine Phosphatases and the regulation of cell signaling: from basic research to new therapeutics

The protein phosphatases are critical, specific regulators of signaling that serve an essential function, in a coordinated manner with the protein kinases, to determine the response to a physiological stimulus. My laboratory takes a multidisciplinary approach to study the structure, regulation and function of the protein tyrosine phosphatase (PTP) family of enzymes, to illustrate their fundamental importance to the control of signal transduction under normal and pathophysiological conditions. As functional studies have established links to disease, the PTPs have been garnering attention as potential therapeutic targets; however, they remain a largely untapped resource for drug development.