Abstract 1238 A secreted Mycobacterial protein hijacks CRL2 ubiquitin ligase complexes to alter endosomal trafficking

Intracellular bacterial pathogens have evolved to avoid detection and destruction by the host cells they infect. Mycobacterium tuberculosis (Mtb), the bacterium that causes tuberculosis and kills ∼1.5 million people every year, has co-evolved with humans for millennia, and as a result, has an impressive collection of host manipulation strategies. Central to Mtb's subversion of host defenses is its arsenal of effector proteins that it secretes into host cells during infection. One class of Mtb effectors is the massive family of PE/PPE proteins, which includes ∼170 proteins encoded by an impressive ∼10% of the Mtb genome.