Abstract 2481 Inhibition of Insulin Secretion Induced by Oxidative Stress Compounds

In Type 1 Diabetes (T1D), inflammatory immune cells release cytokines and reactive aldehydes that target pancreatic islets, resulting in the overproduction of reactive oxygen species (ROS) and the eventual death of the β-cells that normally produce insulin. Due to a lack of key antioxidant enzymes, β-cells are especially prone to protein oxidative damage caused by ROS and reactive aldehydes. It is known that proteins become covalently modified during oxidative stress, but which proteins are targeted in β-cells during early T1D and the effects of this protein damage on insulin secretion are poorly understood.