Abstract 2759 The Ultimate Toxic Couple: Hemoglobin and Carbon Monoxide's bond

Carbon monoxide (CO) poisoning is a life-threatening condition that disrupts the body's ability to deliver oxygen to tissues. The structure of Human Adult Carbonmonoxy Hemoglobin (HbCO A) (2M6Z) reveals how CO binds tightly to the iron atom in the heme group of hemoglobin, interacting specifically with critical residues His93 (proximal histidine) and His64 (distal histidine). This binding results in a new molecular conformation of hemoglobin, where the two histidine residues adjust their positions to stabilize the CO-hemoglobin complex.

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Publication Details

Journal
Journal of Biological Chemistry
Published
2025-05-01
DOI
https://doi.org/10.1016/j.jbc.2025.110059
Primary Topic
Heme Oxygenase-1 and Carbon Monoxide
Type
article
Field-Weighted Citation Impact
0.00
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Abstract 2759 The Ultimate Toxic Couple: Hemoglobin and Carbon Monoxide's bond

Jim Lane, L. A. Carlson, Greta Siess, Sidney Leciejewski et al.
Journal of Biological Chemistry
Heme Oxygenase-1 and Carbon Monoxide
article

Abstract 2759 The Ultimate Toxic Couple: Hemoglobin and Carbon Monoxide's bond

Jim Lane, L. A. Carlson, Greta Siess, Sidney Leciejewski, Aida Thiam
article en

Abstract

Carbon monoxide (CO) poisoning is a life-threatening condition that disrupts the body's ability to deliver oxygen to tissues. The structure of Human Adult Carbonmonoxy Hemoglobin (HbCO A) (2M6Z) reveals how CO binds tightly to the iron atom in the heme group of hemoglobin, interacting specifically with critical residues His93 (proximal histidine) and His64 (distal histidine). This binding results in a new molecular conformation of hemoglobin, where the two histidine residues adjust their positions to stabilize the CO-hemoglobin complex.

Journal of Biological ChemistryVol. 301(5)
Openalex Percentile: Top 88%
Heme Oxygenase-1 and Carbon Monoxide
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Abstract 2759 The Ultimate Toxic Couple: Hemoglobin and Carbon Monoxide's bond — Jim Lane, L. A. Carlson, et al. · Journal of Biological Chemistry (2025) | TGRS Research Map | TGRS