Abstract 2248 Characterizing Cdc14 Phosphatase Function in Cell Wall Stress Response in Candida albicans

Candida albicans is a human fungal pathogen responsible for 45–50% of fungal infections, with rising resistance to conventional antifungal therapies. This growing resistance, coupled with high mortality rates, underscores the need for therapeutic strategies targeting novel fungal virulence mechanisms. The fungal cell wall is an essential structure, vital for maintaining cellular integrity, mediating interactions with the host immune system, providing a barrier against environmental stress, and is the target of current anti-fungal therapies.

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Publication Details

Journal
Journal of Biological Chemistry
Published
2025-05-01
DOI
https://doi.org/10.1016/j.jbc.2025.109645
Primary Topic
Antifungal resistance and susceptibility
Type
article
Field-Weighted Citation Impact
0.00
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article

Abstract 2248 Characterizing Cdc14 Phosphatase Function in Cell Wall Stress Response in Candida albicans

Mark C. Hall, Michelle Lihon
Journal of Biological Chemistry
Antifungal resistance and susceptibility
article

Abstract 2248 Characterizing Cdc14 Phosphatase Function in Cell Wall Stress Response in Candida albicans

Mark C. Hall, Michelle Lihon
article en

Abstract

Candida albicans is a human fungal pathogen responsible for 45–50% of fungal infections, with rising resistance to conventional antifungal therapies. This growing resistance, coupled with high mortality rates, underscores the need for therapeutic strategies targeting novel fungal virulence mechanisms. The fungal cell wall is an essential structure, vital for maintaining cellular integrity, mediating interactions with the host immune system, providing a barrier against environmental stress, and is the target of current anti-fungal therapies.

Journal of Biological ChemistryVol. 301(5)
Purdue University West Lafayette (US)
Zero hunger
Openalex Percentile: Top 83%
Antifungal resistance and susceptibility
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