Abstract 2248 Characterizing Cdc14 Phosphatase Function in Cell Wall Stress Response in Candida albicans
Candida albicans is a human fungal pathogen responsible for 45–50% of fungal infections, with rising resistance to conventional antifungal therapies. This growing resistance, coupled with high mortality rates, underscores the need for therapeutic strategies targeting novel fungal virulence mechanisms. The fungal cell wall is an essential structure, vital for maintaining cellular integrity, mediating interactions with the host immune system, providing a barrier against environmental stress, and is the target of current anti-fungal therapies.
Authors
- Mark C. Hall (ORCID: https://orcid.org/0000-0001-6429-2506)
- Michelle Lihon (ORCID: https://orcid.org/0009-0006-9574-6842)
Institutions
- Purdue University West Lafayette (US)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.109645
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00