Abstract 1483 The phosphorylation-dependent activity of deubiquitinase USP7 in the Shoc2 signaling complex

The ERK1/2 signaling cascade is a tightly regulated fundamental signaling cascade. The Shoc2 scaffold protein plays a pivotal role in modulating ERK1/2 signaling by facilitating the assembly of signaling complexes and amplifying ERK1/2 activity. Our previous studies revealed a dynamic interaction between Shoc2 and the deubiquitinase USP7. USP7 binds to Shoc2 when the ERK1/2 pathway is activated and acts as a molecular switch to control the E3 ubiquitin ligase HUWE1 activity in the Shoc2 complex.