Abstract 1673 Role of Ace1 in Histoplasma capsulatum copper homeostasis and virulence
Histoplasma capsulatum is a dimorphic fungal microorganism and the causative agent of histoplasmosis, a systemic infection. This pathogen primarily infects host macrophages, where it survives and proliferates within phagosomes. To counteract infection, host immune cells employ nutritional immunity strategies, manipulating essential metallic micronutrients, such as iron, zinc and copper (Cu) to inhibit pathogen growth. Copper is vital for cellular functions, despite excessive levels disrupting homeostasis.
Authors
- Fátima Ribeiro‐Dias (ORCID: https://orcid.org/0000-0002-7950-3414)
- Célia Maria de Almeida Soares (ORCID: https://orcid.org/0000-0001-5378-9840)
- Mirelle Garcia Silva‐Bailão (ORCID: https://orcid.org/0000-0003-2053-204X)
- Dayane Moraes (ORCID: https://orcid.org/0000-0002-1031-1465)
- Chad A. Rappleye (ORCID: https://orcid.org/0000-0001-7880-5958)
- Alexandre Melo Bailão (ORCID: https://orcid.org/0000-0001-7754-4047)
Institutions
- Universidade Federal de Goiás (BR)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.109608
- Primary Topic
- Phytoplasmas and Hemiptera pathogens
- Type
- article
- Field-Weighted Citation Impact
- 0.00