Abstract 1671 Electrophysiological Profile of Prion Protein-Deficient Cortical Neurons: Potential Role of Complexin I

The cellular form of the prion protein (PrPC) is a ubiquitously expressed protein, extensively studied in the progression of prion diseases. It also exerts a plethora of physiological functions, among which we hypothesize its role in modulating neuronal excitability and synaptic transmission along network development. In this respect, we employed knock-out models of the prion protein to address this assumption. In this study we aimed at quantifying electrical activity alterations in ex vivo primary cultures devoid of PrPC, while investigating the underlying molecular pathways.