TTI1 contributes to radioresistance by activating ATM pathway in rectal cancer
TTI1 was identified as a critical factor in regulating resistance of RC to irradiation. TTI1 could be regarded as a credible biomarker for predicting radiotherapeutic effect and prognosis. Inhibition of ATM signaling pathway may be a novel method to overcome radioresistance.
Authors
- Wenyi Zhang (ORCID: https://orcid.org/0000-0002-2837-937X)
- Xia Li (ORCID: https://orcid.org/0000-0002-9794-2648)
- Jingying Wang (ORCID: https://orcid.org/0000-0002-9153-1979)
- Yuan Qin (ORCID: https://orcid.org/0000-0002-6028-5808)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1186/s12967-025-06648-3
- Citations
- 1
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.81