Abstract 1790 The number of pseudophosphorylated sites on tau leads to differences in kinetics and amounts of aggregation

Neurofibrillary tangles (NFTs) are intracellular aggregates of the microtubule-associated protein tau. These insoluble aggregates are found in the brain of those affected by Alzheimer's disease (AD) and Alzheimer's disease related dementias (ADRDs) and spreading of these aggregates in the brain have been correlated with cognitive decline. Hyperphosphorylation of tau in disease by kinases such as glycogen synthase kinase 3 β (GSK-3 β) has been hypothesized to cause it to dissociate from microtubules and form NFTs.