Abstract 1586 Characterization of the Structural Forces Stabilizing the FGF1-FGF2 Dimer

In the United States, among other countries, an estimated 145 billion dollars are spent yearly for wound care treatments. Recently, a novel Fibroblast Growth Factor dimer (FGF1-FGF2 dimer) was developed to solve this common issue among patients globally. The FGF1-FGF2 dimer is composed of the two proteins, FGF1 and FGF2, both of which exhibit relatively low physiological stability independently despite possessing promising wound healing qualities. Based on structural and stability analysis, the dimer has been shown to improve the overall stability, function, and efficiency when compared to both proteins.