Using proteomics and single-cell sequencing to analyze the pathogenesis of recurrent implantation failure associated with uterine natural killer cells
Finally, identifying three key genes (AMPD3, H6PD and PAK2) associated with RIF and the regulatory solid roles of HR and PAK2 provided a basis for understanding the molecular mechanism of RIF. Our findings may pave the way for developing targeted therapies to improve pregnancy outcomes in patients with RIF.
Authors
- Xin-Xian Zhang
- HU Yu-qin
- Tingting Zhao (ORCID: https://orcid.org/0000-0002-8649-4851)
- Xiaohua Wu (ORCID: https://orcid.org/0000-0003-4655-9136)
Institutions
- Hebei Medical University (CN)
- Fourth Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Archives of Gynecology and Obstetrics
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1007/s00404-025-08074-8
- Citations
- 2
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- Natural Science Foundation of Hebei Province