Properties of CD8 T-cell-recognized neoantigens in different tumor types
These findings underscore the value of both EL score and HLA binding affinity as key predictors of neoantigen immunogenicity in different tumor types. Furthermore, we demonstrate for the first time an immunodominance hierarchy of neoantigen-specific CD8 T-cell responses across patients in <i>ex vivo</i> expanded TIL cultures.
Authors
- Ton N. Schumacher (ORCID: https://orcid.org/0000-0003-0517-8804)
- Pia Kvistborg (ORCID: https://orcid.org/0000-0002-4988-608X)
- Marit M. van Buuren (ORCID: https://orcid.org/0000-0002-1615-1087)
- John B.A.G. Haanen (ORCID: https://orcid.org/0000-0001-5884-7704)
- Kelly Hoefakker
- Steven L. C. Ketelaars
- Anastasia Gangaev (ORCID: https://orcid.org/0000-0001-6215-6260)
- Paul Baas (ORCID: https://orcid.org/0000-0001-7018-9556)
- Lorenzo F. Fanchi (ORCID: https://orcid.org/0000-0002-5763-6726)
- Sanne Patiwael
- Nienke van Rooij (ORCID: https://orcid.org/0009-0005-4942-5709)
- Marleen Kok
- M. van der Heijden
Institutions
- Leiden University Medical Center (NL)
- The Netherlands Cancer Institute (NL)
- Oncode Institute (NL)
Publication Details
- Journal
- Immuno-Oncology Technology
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1016/j.iotech.2025.101062
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- KWF Kankerbestrijding