Abstract 2092 Atypical p38 Kinase Signaling in Retinal Vascular Damage and Recovery
Alternative therapeutic targets are crucial to complement or replace current anti-VEGF treatments, given their limitations. This study investigates the role of atypical p38 kinase in retinal vascular damage and recovery. By modeling and selectively targeting atypical p38 signaling, this project aims to establish its potential as an alternative therapeutic approach to enhance or support anti-VEGF therapies. Oxygen-induced retinopathy (OIR) was evaluated in C57BL/6 wild-type (WT) and C57BL/6 Tab1KI (TKI) mice, the latter harboring a defect in atypical p38 signaling.
Authors
- Sneha Ghosh
- Abby Young
- Heike Kroeger (ORCID: https://orcid.org/0000-0001-7726-7748)
- Eugene F. Douglass (ORCID: https://orcid.org/0000-0003-3418-9203)
- Fredejah Royer
- Neil Grimsey (ORCID: https://orcid.org/0000-0002-0481-4920)
- Sanjana Gattineni
- Fang Liu (ORCID: https://orcid.org/0000-0002-2073-1682)
- Priya Narayanan (ORCID: https://orcid.org/0000-0003-2059-3651)
Institutions
- Georgia State University (US)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.110114
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Eye Institute