Abstract 1401 Identification of a highly dynamic pathway regulating mitochondrial RNA and cytosolic RNA crosstalk by super-resolution live microscopy

Mitochondria are highly dynamic organelles, which require proper regulation to maintain neuronal health. ALS is a devastating neurodegenerative disease characterized by the loss of upper and lower motor neurons. Of note, misregulation of both mitochondria and RNA have been proposed to contribute to the molecular mechanisms underlying ALS, suggesting that further understanding their crosstalk may shed light on ALS pathogenesis. Moreover, while mitochondria contain their own mtRNA, the mechanisms regulating mtRNA and its ability to be dynamically co-regulated with cytosolic RNA is still not well understood.