Abstract 1968 Heat it up - Non-shivering thermogenesis is intact upon brown-adipocyte specific loss of ATGL and HSL due to white adipose tissue browning
Intracellular fatty acids (FAs) activate and fuel non-shivering thermogenesis (NST) mediated via uncoupling protein 1 (UCP1). Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) are the two main triacylglycerol lipases in adipocytes that control FA availability. We showed previously that a brown adipocyte-specific loss of ATGL does not affect cold-induced thermogenesis in brown adipose tissue (BAT) and NST, raising the question whether HSL-mediated FA release is sufficient to allow NST.
Authors
- Renate Schreiber (ORCID: https://orcid.org/0000-0002-3475-157X)
- Yelina Manandhar
- Dagmar Kratky (ORCID: https://orcid.org/0000-0003-1357-7573)
- Dagmar Kolb (ORCID: https://orcid.org/0000-0002-6387-7446)
- Rudolf Zechner (ORCID: https://orcid.org/0000-0001-5483-1182)
- Nemanja Vujić (ORCID: https://orcid.org/0000-0003-2977-7799)
- Gerald Höefler (ORCID: https://orcid.org/0000-0002-9056-3063)
- Anita Pirchheim
- Peter Höfer (ORCID: https://orcid.org/0000-0003-3646-503X)
Institutions
- University of Graz (AT)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.109498
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00