Abstract 1898 Regulated inhibition of extracellular and intracellular lipolysis

Extracellular lipolysis is an essential step in the uptake of triglycerides by adipose tissue and is catalyzed by the enzyme lipoprotein lipase (LPL). Intracellular lipolysis is essential for mobilizing fatty acids, allowing them to be used internally or exported to other tissues. The key step in intracellular lipolysis is catalyzed by adipose triglyceride lipase (ATGL). The activities of LPL and ATGL are carefully regulated mainly through post-translational mechanisms. During fasting, LPL is inhibited in adipose tissue to prioritize the uptake of plasma triglycerides by other tissues.