Abstract 2736 Antioxidant, Metabolic and Bioenergetic Effects of Novel Mitochondria-Targeted Estrogens
Mitochondrial dysfunction is a common factor in metabolic and neurodegenerative diseases; bone pathologies; and cancer. Estrogens, in addition to their nuclear effects, modulate mitochondrial function by increasing energy production and regulating antioxidant balance. The selective accumulation of estrogens in the mitochondria is a strategy to concentrate their effects and enhance energy metabolism, which would represent an alternative to restore mitochondrial dysfunction. The lipophilic cation triphenylphosphonium (TPP) was coupled to two estrogens: 17β-estradiol, and 17α-ethinylestradiol, generating two novel mitochondria-targeted estrogens (mitoE2 and mitoEE2, respectively).
Authors
- Aldo Moreno‐Ulloa (ORCID: https://orcid.org/0000-0001-7973-4215)
- Alfredo Martı́nez (ORCID: https://orcid.org/0000-0003-4882-4044)
- Rafael Vázquez-Duhalt (ORCID: https://orcid.org/0000-0003-1612-2996)
- Johanna Bernáldez-Sarabia (ORCID: https://orcid.org/0000-0003-4894-5604)
- Carolina Álvarez‐Delgado (ORCID: https://orcid.org/0000-0002-4567-1081)
- Pablo Garrido (ORCID: https://orcid.org/0000-0002-5960-8569)
- Kanchan Chauhan (ORCID: https://orcid.org/0000-0002-5021-3392)
- Geovanni Alberto Ruiz-Romero
- Magdiel Orozco-Valdivia
Institutions
- University of Utah (US)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.109551
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Centro de Investigación Científica y de Educación Superior de Ensenada, Baja California