Abstract 1133 Translational control of HIV-1 unspliced RNA is regulated at the level of transcription through an RNA structure-guided mechanism
The 9.2 kb unspliced viral RNA of Human Immunodeficiency Virus type 1 (HIV-1) serves a dual purpose; it functions as the viral genome, packaged into new viral particles as a dimer, and as the mRNA template for the synthesis of the essential structural proteins Gag and Gag-Pol. During transcription of HIV-1 RNA by host cell RNA polymerase II, various transcription start sites are used resulting in heterogeneous RNAs containing either one (1G), two, or three (3G) 5ʹ guanosines and a modified 5ʹ cap.
Authors
- Crystal I. Stackhouse
- Karin Musier‐Forsyth (ORCID: https://orcid.org/0000-0002-0354-4172)
- Michael G. Kearse (ORCID: https://orcid.org/0000-0002-7025-8803)
- Zetao Cheng (ORCID: https://orcid.org/0009-0003-9420-197X)
- Wei Hu (ORCID: https://orcid.org/0000-0002-0392-6939)
- Joseph D. Puglisi (ORCID: https://orcid.org/0000-0001-9268-5112)
- Olga A. Nikolaitchik
- Joseph Kanlong (ORCID: https://orcid.org/0009-0004-3088-5257)
- Saiful Islam (ORCID: https://orcid.org/0000-0001-5777-9164)
Publication Details
- Journal
- Journal of Biological Chemistry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jbc.2025.109734
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Cancer Institute
- National Institute of Allergy and Infectious Diseases