Abstract 1164 Investigating the molecular mechanism of Hog1 inhibition by combined osmotic stress and oxidative stress

Living systems are frequently exposed to multiple stressors simultaneously, yet most research primarily focuses on responses to individual stressors in isolation. This study investigates how cells respond to the combination of hyperosmolarity and oxidative stress using budding yeast as a model. In response to hyperosmolarity, yeast cells activate the high-osmolarity glycerol (HOG) pathway, which consists of two independent branches converging on the mitogen-activated protein kinase kinase (MAPKK) Pbs2.