Abstract 1870 Crystal structure and ligand-binding specificity of the Borrelia burgdorferi proteins BmpA and BmpB

Borrelia burgdorferi is a diderm bacterium and the causative agent of Lyme disease. Studies have shown that proteins BmpA and BmpB bind to laminin, a key component of the host's extracellular matrix. However, previous research identified a paralogous protein, BmpD, as a nucleoside-binding protein. This raises the question of whether BmpA and BmpB also share this nucleoside-binding function or exclusively bind laminin. To elucidate the structure and function of BmpA, we determined its crystal structure at a resolution of 2.90 Å.