Distinct age-related effects of homologous recombination deficiency on genomic profiling and treatment efficacy in gastric cancer
HRR gene mutations influence genomic profiling, TMB, and MSI differently depending on the age of gastric cancer onset, suggesting potential effects on treatment efficacy and prognosis.
Authors
- Yuki Maki (ORCID: https://orcid.org/0000-0003-3005-5400)
- Masaya Iwamuro (ORCID: https://orcid.org/0000-0002-1757-5754)
- Shinichi Toyooka (ORCID: https://orcid.org/0000-0002-7588-6745)
- Yoshiyasu Kono (ORCID: https://orcid.org/0000-0002-4717-5196)
- Akira Hirasawa
- Toshiki Ozato (ORCID: https://orcid.org/0009-0003-9738-8768)
- Hideki Yamamoto (ORCID: https://orcid.org/0000-0002-1701-7090)
- Shuta Tomida (ORCID: https://orcid.org/0000-0003-3786-936X)
- Motoyuki Otsuka (ORCID: https://orcid.org/0000-0003-2869-2881)
- Daisuke Ennishi (ORCID: https://orcid.org/0000-0003-4788-2103)
- Seiji Kawano (ORCID: https://orcid.org/0000-0002-3741-443X)
- Kenta Hamada
Institutions
- Okayama University (JP)
- Okayama University Hospital (JP)
Publication Details
- Journal
- Journal of Gastroenterology
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1007/s00535-025-02267-3
- Citations
- 3
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- Foundation for Promotion of Cancer Research
- Okayama University