Refinement of histologic subtypes and identification of biomarkers linked to unfavorable prognosis in cholangiocarcinoma: The ENSCCA registries’ framework for digital twin advancement
Our data underline the importance of identifying morphological subclasses with a significant prevalence in CCA as a tool for risk stratification and prognosis. The European CCA Histology Registry represents a valuable platform for integrating digital pathology with clinical, radiological, and molecular information as a framework for digital twin advancement.
Authors
- Konrad Reichel (ORCID: https://orcid.org/0009-0001-0506-5511)
- Gian Luca Grazi (ORCID: https://orcid.org/0000-0002-3279-0313)
- Manuela Martín-Izquierdo
- Lara R. Heij (ORCID: https://orcid.org/0000-0002-0602-3356)
- Laura Izquierdo‐Sánchez (ORCID: https://orcid.org/0000-0002-7016-8314)
- Raffaele Brustia (ORCID: https://orcid.org/0000-0001-6426-9533)
- Stefano Leone (ORCID: https://orcid.org/0000-0001-6339-6397)
- Agostino Maria De Rose (ORCID: https://orcid.org/0000-0003-3310-8088)
- Elio Damato
- Valeria Panebianco (ORCID: https://orcid.org/0000-0001-8466-918X)
- Guido Carpino (ORCID: https://orcid.org/0000-0001-8570-2519)
- Bas Groot Koerkamp (ORCID: https://orcid.org/0000-0003-1917-6973)
- Diletta Overi (ORCID: https://orcid.org/0000-0003-3561-8903)
- Ezio Lanza (ORCID: https://orcid.org/0000-0003-1889-8798)
- Paolo Onori (ORCID: https://orcid.org/0000-0002-7195-3760)
- Pedro M. Rodrigues (ORCID: https://orcid.org/0000-0001-6193-7436)
- Jérémy Augustin (ORCID: https://orcid.org/0000-0001-8194-0624)
- Rocı́o I.R. Macı́as (ORCID: https://orcid.org/0000-0002-4748-0326)
- Ana Lleò (ORCID: https://orcid.org/0000-0002-0561-7902)
- Andrés García-Sampedro (ORCID: https://orcid.org/0000-0002-2286-8623)
- Pilar Acedo
- Eugenio Gaudio (ORCID: https://orcid.org/0000-0001-6180-3091)
- Julien Caldéraro (ORCID: https://orcid.org/0000-0002-5370-0807)
- Stephen P. Pereira (ORCID: https://orcid.org/0000-0003-0821-1809)
- Barbara Franceschini (ORCID: https://orcid.org/0000-0001-6348-248X)
- Cristiana Soldani (ORCID: https://orcid.org/0000-0001-5041-9588)
- Francesco Ardito (ORCID: https://orcid.org/0000-0003-1596-2862)
- Marco Rengo (ORCID: https://orcid.org/0000-0001-9087-5692)
- Vincenzo Cardinale (ORCID: https://orcid.org/0000-0003-0234-3341)
- Timothy James Kendall (ORCID: https://orcid.org/0000-0002-4174-2786)
- Felice Giuliante (ORCID: https://orcid.org/0000-0003-2087-2589)
- Domenico Alvaro (ORCID: https://orcid.org/0000-0003-3771-9644)
- Jesús M. Bañales (ORCID: https://orcid.org/0000-0002-5224-2373)
- Diego Bueno-Sacristán
- Alberto Quaglia (ORCID: https://orcid.org/0000-0002-3333-3579)
- Guido Torzilli
- Michail Doukas (ORCID: https://orcid.org/0000-0002-8611-840X)
- Jose M Hernández-Bayo
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Ikerbasque (ES)
- Humanitas University (IT)
- Inserm (FR)
- University of the Basque Country (ES)
- Universidad de Salamanca (ES)
- Université Paris-Est Créteil (FR)
- University of Cambridge (GB)
- The Royal Free Hospital (GB)
- Instituto de Salud Carlos III (ES)
- CTO Hospital (IT)
- Pancreatic Cancer Action Network (US)
- Centre Hospitalier Universitaire Henri-Mondor (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Complejo Hospitalario de Salamanca (ES)
- Biogipuzkoa Health Research Institute (ES)
- Essen University Hospital (DE)
- Hôpitaux Universitaires Henri-Mondor (FR)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Instituto de Investigación Biomédica de Salamanca (ES)
- Erasmus MC Cancer Institute (NL)
- Centre for Inflammation Research (GB)
- IRCCS Humanitas Research Hospital (IT)
- University of Florence (IT)
- University College London (GB)
- Sapienza University of Rome (IT)
- Universidad de Navarra (ES)
- RWTH Aachen University (DE)
- University of Edinburgh (GB)
Publication Details
- Journal
- Hepatology
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1097/hep.0000000000001425
- Citations
- 2
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.01