An activator of phosphatidylinositol 3-kinase alpha restores cardioprotection from ischaemia/reperfusion injury in mice with coronary atherosclerosis or insulin resistance
The double-mutant SR-BIΔCT/ΔCT;Ldlr KO mouse strain may be a more clinically translatable mouse model of I/R and cardioprotection. Furthermore, UCL-TRO-1938 is a promising cardioprotective drug as it remains effective in a mouse model with CAD.
Authors
- Sean M. Davidson (ORCID: https://orcid.org/0000-0001-5182-4980)
- David Z. Z. He (ORCID: https://orcid.org/0000-0001-8383-9634)
- Pelin Golforoush
- Derek M. Yellon (ORCID: https://orcid.org/0000-0001-7791-9320)
- Elias Sulaiman (ORCID: https://orcid.org/0000-0001-5509-0718)
Institutions
- Cardiovascular Institute of the South (US)
- University College London (GB)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1093/cvr/cvaf111
- Citations
- 2
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 2.94