Anti-angiogenic therapy combined with immune checkpoint blockade mediates CCR7+CD8+ T-cell entry into HCC through high endothelial venules
HEVs are pivotal in modulating immune activity within the HCC tumor microenvironment. Targeting the VEGFC-NF-κB (non-canonical)-HEV axis could be a promising therapeutic strategy to enhance antitumor immunity and improve outcomes in patients with HCC who are receiving combination AAD plus ICB therapy.
Authors
- Juan Huang (ORCID: https://orcid.org/0000-0003-2901-7175)
- Tian Di (ORCID: https://orcid.org/0000-0003-4107-5917)
- Xiuxia Lu (ORCID: https://orcid.org/0000-0002-1620-197X)
- Yueyang Yu (ORCID: https://orcid.org/0000-0001-8771-0811)
- Jiliang Qiu (ORCID: https://orcid.org/0000-0002-0329-074X)
- Lian Li (ORCID: https://orcid.org/0000-0003-0097-1184)
- Lili Liu (ORCID: https://orcid.org/0000-0002-4347-2038)
- Yingwen Hou (ORCID: https://orcid.org/0000-0002-6012-115X)
- Lin Tian (ORCID: https://orcid.org/0000-0003-3661-4453)
- Zhimei Huang (ORCID: https://orcid.org/0000-0002-4136-5896)
- Yiquan Jiang
- Jinhua Huang (ORCID: https://orcid.org/0000-0001-9750-1319)
- Ling Gu (ORCID: https://orcid.org/0000-0003-0450-5893)
- Xue Han (ORCID: https://orcid.org/0000-0001-5569-3113)
- Limin Zheng (ORCID: https://orcid.org/0000-0002-8281-1450)
- Lu Tang (ORCID: https://orcid.org/0009-0009-9572-3028)
Institutions
- Harbin Medical University (CN)
- Sun Yat-sen University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Hepatology
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1097/hep.0000000000001426
- Citations
- 2
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.59