Poor Correlation Between Inflammatory and Brain Injury Biomarkers After Neonatal Intraventricular Hemorrhage: A Pilot Study
This study found no significant correlation between CSF hemoglobin, TNF-α, and GFAP in the first weeks of CSF diversion in neonates with IVH. There is high variability of these measures, even within subjects. This study reveals the need for further research into neuroinflammatory and brain injury biomarkers in neonates with IVH, their usefulness in clinical decision-making, and long-term outcomes.
Authors
- Thao Nguyen (ORCID: https://orcid.org/0000-0001-6193-9271)
- Stephen A. Fletcher (ORCID: https://orcid.org/0000-0002-1874-0790)
- David I. Sandberg (ORCID: https://orcid.org/0000-0002-0245-6461)
- Manish N. Shah (ORCID: https://orcid.org/0000-0002-2628-465X)
- Ashley Collier
- Brandon A. Miller (ORCID: https://orcid.org/0000-0002-0780-8358)
- Ankit Agarwal (ORCID: https://orcid.org/0000-0003-4963-7101)
- Miriam Zamorano
- Braden Oldham
- Kaleigh Riggs‐Harpur
Institutions
- Medical University of South Carolina (US)
- The University of Texas Health Science Center (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- World Neurosurgery
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1016/j.wneu.2025.124177
- Citations
- 3
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 10.48
Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke