Immune Checkpoint Inhibitors for Microsatellite Instability High Unresectable Obstructive Colon Cancer: A Report of Two Cases
This report highlights the potential benefits of ICI treatment for dMMR/MSI-H OCC, particularly for rapid relief of obstruction-related symptoms and facilitating oncologically safe R0 resection. In cases of MSI-H OCC, ICIs can be highly effective as an alternative to traditional decompression procedures.
Authors
- Akihisa Matsuda (ORCID: https://orcid.org/0000-0002-6468-9375)
- Takamichi Matsui
- Hiroshi Yoshida (ORCID: https://orcid.org/0000-0002-2463-9023)
- Takuma Iwai (ORCID: https://orcid.org/0000-0002-4706-1228)
- Shintaro Kanaka (ORCID: https://orcid.org/0000-0002-9466-2229)
- Toshimitsu Miyasaka (ORCID: https://orcid.org/0000-0003-4066-0479)
- Seiichi Shinji (ORCID: https://orcid.org/0000-0002-9204-6393)
- Takeshi Yamada (ORCID: https://orcid.org/0000-0002-1436-7482)
- Goro Takahashi (ORCID: https://orcid.org/0000-0002-8561-8349)
- Daigo Yoshimori (ORCID: https://orcid.org/0009-0005-5398-7544)
- Yasuyuki Yokoyama (ORCID: https://orcid.org/0009-0002-6343-7982)
- Keisuke Uehara (ORCID: https://orcid.org/0000-0001-9669-5860)
- Koki Hayashi (ORCID: https://orcid.org/0000-0002-9571-6831)
Institutions
- Nippon Medical School Hospital (JP)
Publication Details
- Journal
- Surgical Case Reports
- Published
- 2025-01-01
- DOI
- https://doi.org/10.70352/scrj.cr.25-0070
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00