Default mode network static-dynamic functional signatures in first-episode drug-naive major depressive disorder
•In this study, we investigated the altered static and dynamic function of DMN in first-episode drug-naive MDD (FEDN) for the first time.•We found that the TV of dMPFC in FEDN was significantly increased, while the sFC within DMN were decreased both in FEND and rMDD.•In addition, we found that the TV of dMPFC in FEDN was significantly positively associated with HAMD-24 scores.•These findings provide evidence for disorder-specific abnormal functional patterns and offered a new perspective for future research on fluctuating dynamic neural communication in FEDN.
Authors
- Keyue Ding (ORCID: https://orcid.org/0000-0002-3496-6415)
- Youyong Kong (ORCID: https://orcid.org/0000-0003-2095-8470)
- Yonggui Yuan (ORCID: https://orcid.org/0000-0001-6496-3998)
- Zhenghua Hou (ORCID: https://orcid.org/0000-0002-7421-7304)
- Yingying Yin (ORCID: https://orcid.org/0000-0003-2538-7777)
- Fan Li (ORCID: https://orcid.org/0000-0003-2584-3162)
- Xiaotong Zhang (ORCID: https://orcid.org/0000-0003-3994-0692)
- Xiaoyun Liu (ORCID: https://orcid.org/0000-0003-0854-6190)
Institutions
- Jiangsu University (CN)
- Zhongda Hospital Southeast University (CN)
- Zhanjiang Experimental Station (CN)
- Southeast University (CN)
Publication Details
- Journal
- Comprehensive Psychoneuroendocrinology
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1016/j.cpnec.2025.100306
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00