Ion interference induced by Ca-Mn nanoplatform enhances ferroptosis and promotes immune response for osteosarcoma treatment
In conclusion, HMnO<sub>2</sub>@CaO<sub>2</sub> nanoplatform enhances tumor therapy efficacy by overcoming ferroptosis limitations, inducing Ca<sup>2+</sup> overload, and boosting anti-tumor immunity. This strategy offers a promising approach to ion interference in the clinical translation of nanomedicines. Furthermore, it marks a significant advancement in osteosarcoma (OS) treatment and underscores the transformative potential of nanotechnology in medicine.
Authors
- Chengqing Yi (ORCID: https://orcid.org/0000-0002-1103-456X)
- Shuo Shi (ORCID: https://orcid.org/0000-0003-4387-3445)
- Zikang Wang (ORCID: https://orcid.org/0000-0003-4995-5521)
- Mengyao Chen (ORCID: https://orcid.org/0000-0002-3183-8426)
- Chen Li (ORCID: https://orcid.org/0000-0002-2071-7709)
- Minyi Zhang (ORCID: https://orcid.org/0000-0003-0059-2440)
- Qi Wang (ORCID: https://orcid.org/0000-0002-1588-9047)
- Chunhui Wang (ORCID: https://orcid.org/0000-0001-9247-397X)
- Xia Tao
Institutions
- Pudong Medical Center (CN)
- Shanghai Tenth People's Hospital (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1016/j.jare.2025.06.022
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China