Targeting HSV-1 glycoprotein D through riboflavin-mediated photodynamic therapy: Insights from bioinformatics analysis and in vitro evaluation

The study's findings indicate that riboflavin, possessing drug-like characteristics, can successfully engage with glycoprotein D, demonstrating a high binding affinity. Additionally, PDT using riboflavin has been shown to effectively suppress HSV-1 replication. Consequently, riboflavin-mediated PDT, by lowering viral load, emerges as a promising supplementary treatment for HSV-1.