Successful treatment of severe venous leg ulcers and diabetic foot ulcers using ozone

OOT demonstrated substantial efficacy in reducing infection, alleviating pain, and promoting wound healing in patients with severe VLUs and DFUs, restoring their healthy, normal limbs. These findings support the use of OOT as a valuable adjunctive treatment. Further large-scale, randomized trials are needed to optimize treatment protocols and confirm long-term benefits.

Authors

Luigi Valdenassi
Salvatore Chirumbolo (ORCID: https://orcid.org/0000-0003-1789-8307)
Giuseppe Masiello
Francesco Vaiano
Tommaso Richelmi (ORCID: https://orcid.org/0009-0002-3679-8619)
Marianno Franzini
Umberto Tirelli

Institutions

University of Verona (IT)
University of Pavia (IT)
National Cancer Institute (UA)
Italian Society of Periodontology and Implantology (IT)

Publication Details

Journal: Journal of Vascular Surgery Venous and Lymphatic Disorders
Published: 2025-06-13
DOI: https://doi.org/10.1016/j.jvsv.2025.102278
Citations: 1
Primary Topic: Medical and Biological Ozone Research
Type: article
Field-Weighted Citation Impact: 1.39

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article

Successful treatment of severe venous leg ulcers and diabetic foot ulcers using ozone

Luigi Valdenassi, Salvatore Chirumbolo, Giuseppe Masiello, Francesco Vaiano et al.

Jun 13, 2025

1 citations

Journal of Vascular Surgery Venous and Lymphatic Disorders

Medical and Biological Ozone Research

1.39

article

Successful treatment of severe venous leg ulcers and diabetic foot ulcers using ozone

Luigi Valdenassi, Salvatore Chirumbolo, Giuseppe Masiello, Francesco Vaiano, Tommaso Richelmi, Marianno Franzini, Umberto Tirelli

June 13, 2025article en

1 citations

Abstract

OOT demonstrated substantial efficacy in reducing infection, alleviating pain, and promoting wound healing in patients with severe VLUs and DFUs, restoring their healthy, normal limbs. These findings support the use of OOT as a valuable adjunctive treatment. Further large-scale, randomized trials are needed to optimize treatment protocols and confirm long-term benefits.

Journal of Vascular Surgery Venous and Lymphatic DisordersVol. 13(6)

University of Verona (IT), University of Pavia (IT), National Cancer Institute (UA), Italian Society of Periodontology and Implantology (IT)

Zero hunger

Openalex Percentile: Top 19%

Medical and Biological Ozone Research

1.39

DOI Open Access PDF OpenAlex

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Successful treatment of severe venous leg ulcers and diabetic foot ulcers using ozone — Luigi Valdenassi, Salvatore Chirumbolo, et al. · Journal of Vascular Surgery Venous and Lymphatic Disorders (2025) | TGRS Research Map | TGRS