The coupling of global brain activity and cerebrospinal fluid flow as a potential predictive marker of brain amyloid-β accumulation
Weaker gBOLD-CSF coupling precedes brain Aβ accumulation, indicating its potential as a predictive marker for amyloid conversion. Future studies should refine clinical thresholds for early intervention strategies in AD prevention.
Authors
- Yuya Saito (ORCID: https://orcid.org/0000-0002-4033-1424)
- Kaito Takabayashi (ORCID: https://orcid.org/0000-0002-5562-1504)
- Akifumi Hagiwara (ORCID: https://orcid.org/0000-0001-5277-3249)
- Osamu Abe (ORCID: https://orcid.org/0000-0002-1180-2629)
- Akihiko Wada (ORCID: https://orcid.org/0000-0003-3432-0267)
- Yuya Tanaka (ORCID: https://orcid.org/0000-0003-0260-0424)
- Christina Andica (ORCID: https://orcid.org/0000-0002-9339-6950)
- Toshiaki Akashi (ORCID: https://orcid.org/0000-0002-3056-0792)
- Wataru Uchida (ORCID: https://orcid.org/0000-0002-8453-1532)
- Koji Kamagata (ORCID: https://orcid.org/0000-0001-5028-218X)
- Shigeki Aoki (ORCID: https://orcid.org/0000-0003-2821-0651)
- Rinako Iseki
Institutions
- Juntendo University (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- The Journal of Prevention of Alzheimer s Disease
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1016/j.tjpad.2025.100228
- Citations
- 1
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.91